Hillary Clinton has wrestled with allegations surrounding her husband’s infidelities for much of their 40-year marriage, including a sexual harassment lawsuit, a grand jury investigation and an impeachment vote centered on his untruthfulness about a relationship with a White House intern.

Now, her Republican opponent Donald Trump and his surrogates have signaled that he may bring up the subject in the next presidential debate, treacherous territory, given his own infidelities and treatment of women.

Clinton’s friends say they have seen her deal with Bill Clinton’s conduct before, bristling at threats and countering them with steely determination. Her reaction, said longtime Arkansas friend Jim Blair, is to face accusers and respond thusly: “These people are not going to run over us.”