BEVERLY HILLS, Calif. — Rob Lowe, who has publicly aligned himself with the Democratic party in the past, says it was not a concern to take on a TV movie adaptation of Fox News pundit and conservative Bill O’Reilly’s book Killing Kennedy.

“I didn’t think about it at all because the book had come out and been so successful,” said Lowe at the annual Television Critics Association panel Wednesday in Beverly Hills.

O’Reilly’s Killing Kennedy, which came out last year and was a best-seller, examined the events leading up to President John F. Kennedy’s death.

Lowe plays Kennedy in the film, and says like O’Reilly’s book, National Geographic Channel’s version will present a unique perspective on the country’s 35th president....