The mysterious fall of the largest of the world's earliest urban civilizations nearly 4,000 years ago in what is now India, Pakistan, Nepal and Bangladesh now appears to have a key culprit — ancient climate change, researchers say.

Ancient Egypt and Mesopotamia may be the best known of the first great urban cultures, but the largest was the Indus or Harappan civilization. This culture once extended over more than 386,000 square miles (1 million square kilometers) across the plains of the Indus River from the Arabian Sea to the Ganges, and at its peak may have accounted for 10 percent of the world population. The civilization developed about 5,200 years ago, and slowly disintegrated between 3,900 and 3,000 years ago — populations largely abandoned cities, migrating toward the east.

"Antiquity knew about Egypt and Mesopotamia, but the Indus civilization, which was bigger than these two, was completely forgotten until the 1920s," said researcher Liviu Giosan, a geologist at Woods Hole Oceanographic Institution in Massachusetts. "There are still many things we don't know about them." [Photos: Life and Death of Ancient Urbanites]...